Sin is an utterance, a deed, or a desire contrary to the eternal law.2 It is an offense against God. It rises up against God in a disobedience contrary to the obedience of Christ.
The root of all sins lies in man’s heart. The kinds and the gravity of sins are determined principally by their objects.
To choose deliberately—that is, both knowing it and willing it—something gravely contrary to the divine law and to the ultimate end of man is to commit a mortal sin. This destroys in us the charity without which eternal beatitude is impossible. Unrepented, it brings eternal death.
Rom 11:32.
St. Augustine, Faust 22: PL 42, 418.